Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 11/20 | 0.44 |
| ▸ | RAB9A | P51151 | 10/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902734 | 0.89 | KDM4E (0.49) | KDM4ENPC1RAB9ACASP3SENP8 | |
| SCHEMBL19902738 | 0.75 | RAB9A (0.46) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL19902747 | 0.74 | ATM (0.46) | KDM4ESMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19902741 | 0.72 | KDM4E (0.52) | KDM4ENPC1RAB9ACASP3SENP8 | |
| SCHEMBL11452798 | 0.71 | NPC1 (0.48) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4862360 | 0.69 | KDR (0.56) | KDM4ENPC1RAB9AMAPTKDR | |
| SCHEMBL17064036 | 0.68 | P2RX7 (0.38) | KDM4ENPC1MAPTL3MBTL1MAPK1 | |
| SCHEMBL258368 | 0.68 | KDM4E (0.53) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL17714455 | 0.68 | TDP1 (0.50) | KDM4EMAPTSMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL18790103 | 0.68 | P2RX7 (0.45) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |