SCHEMBL19902966

SCHEMBL19902966

Cc1cnc2cccc(C(=O)N=O)c2n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 7/20 0.41
PARP2 Q9UGN5 1/20 0.39
ALDH1A1 P00352 1/20 0.38
MAPT P10636 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
HSD17B10 Q99714 1/20 0.35
KDR P35968 2/20 0.35
TNKS2 Q9H2K2 1/20 0.35
KMT2A Q03164 2/20 0.33
KDM4E B2RXH2 2/20 0.33
GAA P10253 1/20 0.33
ATM Q13315 1/20 0.33
HCRTR1 O43613 1/20 0.33
HCRTR2 O43614 1/20 0.33
GRM5 P41594 1/20 0.33
PDK2 Q15119 1/20 0.33
PDK4 Q16654 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2629409 0.83 ALDH1A1 (0.57) PARP1PARP2ALDH1A1MAPTCYP1A2
SCHEMBL2606617 0.81 PARP1 (0.59) PARP1PARP2
SCHEMBL16572979 0.79 PLK1 (0.45) PARP1PARP2MAPTCYP1A2CYP2C9
SCHEMBL2605000 0.78 ALDH1A1 (0.41) PARP1PARP2ALDH1A1MAPTCYP1A2
SCHEMBL14406054 0.78 P2RX7 (0.49) PARP1PARP2ALDH1A1MAPTCYP1A2
SCHEMBL4777457 0.75 PARP1 (0.58) PARP1PARP2ALDH1A1MAPTCYP1A2
SCHEMBL1041134 0.72 ACHE (0.57) PARP1ALDH1A1MAPTCYP1A2CYP2C9
SCHEMBL8404385 0.71 ADORA3 (0.44) ALDH1A1MAPTCYP1A2KMT2AKDM4E
SCHEMBL13393526 0.70 ALDH1A1 (0.57) PARP1ALDH1A1MAPTCYP1A2CYP2C9
SCHEMBL7451226 0.68 NR4A2 (0.46) PARP1ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3287454-B1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2020-09-02 EP disclosed
EP-3287454-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2018-02-28 EP disclosed