Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12853799 | 0.85 | NLRP3 (0.33) | NLRP3 | |
| SCHEMBL24438183 | 0.84 | CA1 (0.37) | KDM5AKDM4CALDH1A1LMNATP53 | |
| SCHEMBL19544689 | 0.82 | KDM5A (0.33) | KDM5AKDM4C | |
| SCHEMBL20760705 | 0.79 | LTA4H (0.36) | KDM5AKDM4C | |
| SCHEMBL16063016 | 0.79 | APP (0.41) | KDM5AKDM4CLMNA | |
| SCHEMBL19545190 | 0.79 | KDM5A (0.32) | KDM5AKDM4C | |
| SCHEMBL14885533 | 0.77 | ALDH1A1 (0.45) | ALDH1A1LMNATP53NLRP3 | |
| SCHEMBL19699975 | 0.76 | ALDH1A1 (0.31) | ALDH1A1LMNATP53 | |
| SCHEMBL15592245 | 0.76 | — | — | |
| SCHEMBL15996472 | 0.74 | KDM5A (0.32) | KDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3131905-B1 | SPIRO UREA COMPOUNDS AS RSV ANTIVIRAL COMPOUNDS | JANSSEN SCIENCES IRELAND UC (IE) | 2018-02-28 | — | — | EP | disclosed |