Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18065483 | 0.79 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2CHSD17B3 | |
| SCHEMBL18065482 | 0.79 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2CHSD17B3 | |
| Methane SCHEMBL28207060 | 0.78 | ADRA2A (0.36) | ADRA2AADRA2BADRA2CDPP8DPP9 | |
| SCHEMBL1794485 | 0.74 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL24275671 | 0.71 | TDP2 (0.41) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL3346479 | 0.71 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL16101649 | 0.70 | PDK2 (0.44) | PNMTADRA2ATDP2ASIC3CMA1 | |
| SCHEMBL16101650 | 0.70 | PDK2 (0.44) | PNMTADRA2ATDP2ASIC3CMA1 | |
| SCHEMBL7920039 | 0.70 | PNMT (0.39) | PNMTADRA2AADRA2BADRA2CDPP8 | |
| SCHEMBL31537527 | 0.70 | ESR1 (0.40) | DPP8DPP9DPP7TDP2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976341-B1 | ACYCLIC CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-02-28 | — | — | EP | disclosed |