SCHEMBL19903512

SCHEMBL19903512

N#Cc1c(F)cc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.47
CYP11B1 P15538 1/20 0.44
CYP11B2 P19099 1/20 0.44
KIF11 P52732 2/20 0.40
CTSS P25774 2/20 0.39
CTSK P43235 1/20 0.39
RXRA P19793 5/20 0.38
RXRG P48443 4/20 0.38
RXRB P28702 4/20 0.38
EGLN2 Q96KS0 2/20 0.36
NAAA Q02083 1/20 0.35
ALDH1A1 P00352 2/20 0.33
MAPT P10636 2/20 0.33
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
RPS6KA3 P51812 1/20 0.33
JAK3 P52333 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19912364 0.88 TRPV4 (0.40) TRPV4CYP11B1CYP11B2KIF11CTSS
SCHEMBL28994625 0.87 TRPV4 (0.54) TRPV4CYP11B1CYP11B2KIF11CTSS
SCHEMBL19903462 0.79 CYP11B1 (0.48) TRPV4CYP11B1CYP11B2KIF11CTSS
SCHEMBL14148808 0.79 KIF11 (0.41) CYP11B1CYP11B2KIF11CTSSCTSK
SCHEMBL17711112 0.77 CTSS (0.37) TRPV4CYP11B1CYP11B2KIF11CTSS
SCHEMBL15958871 0.76 TRPV4 (0.42) TRPV4KIF11ALDH1A1MAPTKDM4E
SCHEMBL19903571 0.75 AKR1C3 (0.39) TRPV4CYP11B1CYP11B2KIF11CTSS
SCHEMBL9482063 0.75 RXRA (0.54) KIF11RXRARXRGRXRBALDH1A1
SCHEMBL31173987 0.74 TRPV4 (0.41) TRPV4CYP11B1CYP11B2KIF11ALDH1A1
SCHEMBL25991790 0.74 AR (0.41) CYP11B1CYP11B2ALDH1A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10439151-B2 Organic molecules, especially for use in organic optoelectronic devices CYNORA GMBH (DE) 2019-10-08 US disclosed
EP-3360945-B1 ORGANIC ELECTROLUMINESCENT DEVICE CYNORA GMBH (DE) 2019-04-24 EP disclosed
EP-3287450-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-03-20 EP disclosed
US-20180062086-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2018-03-01 US disclosed
EP-3287450-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-02-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10439151-B2 Organic molecules, especially for use in organic optoelectronic devices OR10J3, ORC3, AOC3 TRPV4 1310/4885CYP11B1 877/4885CYP11B2 601/4885
US-20180062086-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, ORC3, AOC3 TRPV4 1280/4885CYP11B1 823/4885CYP11B2 550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.