Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.46 |
| ▸ | PDCD1LG2 | Q9BQ51 | 3/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30384759 | 1.00 | CD274 (0.46) | CD274PDCD1LG2PDE5APDE11APDE10A | |
| SCHEMBL23863511 | 0.72 | PDE10A (0.48) | CD274PDCD1LG2PDE5APDE11APDE10A | |
| SCHEMBL21130555 | 0.72 | PDE10A (0.48) | CD274PDCD1LG2PDE5APDE11APDE10A | |
| SCHEMBL14344767 | 0.71 | ACHE (0.64) | CD274PDCD1LG2PDCD1MAPTTSHR | |
| SCHEMBL15130361 | 0.70 | LTA4H (0.46) | KDM4ETLR7ALDH1A1GAA | |
| SCHEMBL26580970 | 0.69 | CD274 (0.43) | CD274PDCD1LG2PDE5APDE11APDE10A | |
| SCHEMBL19903742 | 0.69 | PNP (0.30) | — | |
| SCHEMBL13463043 | 0.68 | MAPT (0.55) | CD274PDCD1LG2PDCD1KDM4EMAPT | |
| SCHEMBL10272308 | 0.67 | ALDH1A1 (0.57) | ALDH1A1 | |
| SCHEMBL29027742 | 0.67 | ALDH1A1 (0.53) | CD274PDCD1KDM4ESYKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2804861-B1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | GENOSCO (US) | 2018-02-28 | — | — | EP | disclosed |