Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.43 |
| ▸ | PDCD1LG2 | Q9BQ51 | 3/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809138 | 0.84 | ALDH1A1 (0.40) | CD274PDCD1LG2PDCD1SYKALDH1A1 | |
| SCHEMBL26038021 | 0.84 | CD274 (0.38) | CD274PDCD1LG2PDCD1SYKALDH1A1 | |
| SCHEMBL26043540 | 0.72 | LMNA (0.49) | ALDH1A1KDM4EHPGDGAAMAPK1 | |
| SCHEMBL31662619 | 0.72 | ALDH1A1 (0.57) | ALDH1A1PDE2APDE10ATSHRKDM4E | |
| SCHEMBL31663310 | 0.70 | MAPT (0.43) | ALDH1A1PDE2APDE10AHPGDHTT | |
| SCHEMBL21130555 | 0.70 | PDE10A (0.48) | CD274PDCD1LG2PDCD1SYKALDH1A1 | |
| SCHEMBL23863511 | 0.70 | PDE10A (0.48) | CD274PDCD1LG2PDCD1SYKALDH1A1 | |
| SCHEMBL26032241 | 0.69 | GAA (0.44) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL19903801 | 0.69 | CD274 (0.46) | CD274PDCD1LG2PDCD1SYKALDH1A1 | |
| SCHEMBL30384759 | 0.69 | CD274 (0.46) | CD274PDCD1LG2PDCD1SYKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | CD274 1983/4885PDCD1LG2 433/4885PDCD1 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.