Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 7/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1985617 | 1.00 | SIGMAR1 (0.46) | SIGMAR1HTR6MCHR1CHRNA7PADI4 | |
| SCHEMBL1985517 | 1.00 | SIGMAR1 (0.46) | SIGMAR1HTR6MCHR1CHRNA7PADI4 | |
| SCHEMBL1990395 | 1.00 | SIGMAR1 (0.46) | SIGMAR1HTR6MCHR1CHRNA7PADI4 | |
| SCHEMBL1985618 | 1.00 | SIGMAR1 (0.46) | SIGMAR1HTR6MCHR1CHRNA7PADI4 | |
| SCHEMBL1985516 | 1.00 | SIGMAR1 (0.46) | SIGMAR1HTR6MCHR1CHRNA7PADI4 | |
| SCHEMBL1985612 | 0.81 | PADI4 (0.31) | CHRNA7PADI4 | |
| SCHEMBL1985611 | 0.81 | PADI4 (0.31) | CHRNA7PADI4 | |
| SCHEMBL15869705 | 0.79 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL1992104 | 0.79 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL1988808 | 0.79 | HTR6 (0.48) | HTR6MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778959-B2 | AZA-bridged ring-fused indoles and indolines | ABBVIE INC. (US) | 2014-07-15 | — | — | US | claimed |
| US-20110152306-A1 | AZA-BRIDGED RING-FUSED INDOLES AND INDOLINES | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | claimed |
| US-8778959-B2 | AZA-bridged ring-fused indoles and indolines | ABBVIE INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20110152306-A1 | AZA-BRIDGED RING-FUSED INDOLES AND INDOLINES | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152306-A1 | AZA-BRIDGED RING-FUSED INDOLES AND INDOLINES | INMT, IDO1, IDO2 | SIGMAR1 2033/4885HTR6 134/4885MCHR1 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.