Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 10/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904658 | 1.00 | ACACB (0.41) | ACACBNOTUMHTR1ACCR1GPBAR1 | |
| SCHEMBL19904383 | 0.94 | ACACB (0.38) | ACACBNOTUMHTR1ACCR1GPBAR1 | |
| SCHEMBL19904662 | 0.90 | ACACB (0.43) | ACACBNOTUMHTR1ACCR1GPBAR1 | |
| SCHEMBL19904665 | 0.88 | HTR1A (0.41) | NOTUMHTR1ACCR1GPBAR1CHRM4 | |
| SCHEMBL19904392 | 0.88 | ACACB (0.47) | ACACBNOTUMHTR1ACCR1 | |
| SCHEMBL19904696 | 0.86 | NOTUM (0.50) | NOTUMHTR1ACCR1GPBAR1 | |
| SCHEMBL19904428 | 0.85 | UGCG (0.43) | ACACBNOTUMHTR1ACCR1 | |
| SCHEMBL19904316 | 0.85 | UGCG (0.43) | ACACBNOTUMHTR1ACCR1 | |
| SCHEMBL19904478 | 0.85 | UGCG (0.43) | ACACBNOTUMHTR1ACCR1 | |
| SCHEMBL19904387 | 0.84 | ACACB (0.40) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |