Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19908188 | 0.88 | ALK (0.33) | MTORRPTORMLST8 | |
| SCHEMBL1600761 | 0.87 | — | — | |
| SCHEMBL13676587 | 0.80 | MET (0.32) | MTORRPTORMLST8 | |
| SCHEMBL19908236 | 0.76 | ALK (0.30) | — | |
| SCHEMBL1601712 | 0.76 | ALK (0.32) | MTORRPTORMLST8 | |
| SCHEMBL1601286 | 0.75 | MET (0.43) | — | |
| SCHEMBL17813461 | 0.74 | BRPF1 (0.42) | MTORRPTORMLST8 | |
| SCHEMBL19908280 | 0.73 | ALK (0.41) | MTORRPTORMLST8 | |
| SCHEMBL1602379 | 0.68 | NTRK1 (0.33) | — | |
| SCHEMBL17807799 | 0.67 | MTOR (0.38) | MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |