Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21078112 | 0.79 | HPGD (0.42) | JAK1JAK2TYK2HPGDCHRNB2 | |
| SCHEMBL17342884 | 0.79 | KEAP1 (0.43) | JAK1JAK2TYK2HPGDCHRNB2 | |
| SCHEMBL19220893 | 0.76 | HPGD (0.40) | JAK1JAK2TYK2HPGDCHRNB2 | |
| SCHEMBL27392251 | 0.76 | QDPR (0.47) | HPGDTDP1ALDH1A1NAMPTKDM4E | |
| SCHEMBL23619682 | 0.75 | MAPT (0.40) | JAK1JAK2TYK2HPGDCHRNB2 | |
| SCHEMBL25628756 | 0.75 | HPGD (0.39) | JAK1JAK2TYK2HPGDCHRNB2 | |
| SCHEMBL21077918 | 0.72 | ALDH1A1 (0.48) | KEAP1ALDH1A1NAMPTTSHR | |
| SCHEMBL21078144 | 0.72 | KEAP1 (0.44) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL19226370 | 0.72 | KEAP1 (0.48) | HPGDKEAP1ALDH1A1NAMPTTSHR | |
| SCHEMBL17888264 | 0.72 | KEAP1 (0.51) | KEAP1ALDH1A1NAMPTTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935248-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-02-28 | — | — | EP | disclosed |