Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 14/20 | 0.54 |
| ▸ | CTSB | P07858 | 13/20 | 0.54 |
| ▸ | CTSK | P43235 | 4/20 | 0.49 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21403460 | 1.00 | CTSS (0.54) | CTSSCTSBCTSKCTSFCTSL | |
| SCHEMBL1556742 | 0.87 | CTSS (0.65) | CTSSCTSBCTSKCTSFCTSL | |
| SCHEMBL1556740 | 0.87 | CTSS (0.65) | CTSSCTSBCTSKCTSFCTSL | |
| SCHEMBL6737504 | 0.87 | CTSL (0.63) | CTSSCTSBCTSKCTSL | |
| SCHEMBL6737501 | 0.87 | CTSL (0.63) | CTSSCTSBCTSKCTSL | |
| SCHEMBL6737520 | 0.86 | CTSB (0.69) | CTSSCTSBCTSKCTSFCTSL | |
| SCHEMBL1990970 | 0.86 | CTSB (0.38) | CTSSCTSBCTSKCTSFCTSL | |
| SCHEMBL6740880 | 0.86 | CTSB (0.38) | CTSSCTSBCTSKCTSFCTSL | |
| SCHEMBL6744795 | 0.84 | CTSL (0.57) | CTSSCTSBCTSKCTSL | |
| SCHEMBL1558022 | 0.84 | CTSL (0.57) | CTSSCTSBCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040014796-A1 | Novel compounds and compositions as cathepsin S inhititors | AXYS PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | claimed |
| US-6492362-B1 | Compounds and compositions as cathepsin S inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-12-10 | — | — | US | claimed |
| WO-2001019808-A1 | CHEMICAL COMPOUNDS AND COMPOSITIONS AND THEIR USE AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | claimed |
| US-20200197334-A1 | Paediatric Compositions For Treating Multiple Sclerosis | NOVARTIS AG (CH) | 2020-06-25 | — | — | US | disclosed |
| EP-3545953-A1 | PAEDIATRIC COMPOSITIONS FOR TREATING1 MULTIPLE SCLEROSIS | Novartis AG (CH) | 2019-10-02 | — | — | EP | disclosed |
| US-20190117593-A1 | Paediatric Compositions for Treating Multiple Sclerosis | NOVARTIS AG (CH) | 2019-04-25 | — | — | US | disclosed |
| US-20180177747-A1 | Paediatric Compositions For Treating Multiple Sclerosis | NOVARTIS AG (CH) | 2018-06-28 | — | — | US | disclosed |
| US-20170333368-A1 | Paediatric Compositions For Treating Multiple Sclerosis | NOVARTIS AG (CH) | 2017-11-23 | — | — | US | disclosed |
| US-20170128389-A1 | Paediatric Compositions For Treating Multiple Sclerosis | NOVARTIS AG (CH) | 2017-05-11 | — | — | US | disclosed |
| US-20160206574-A1 | Paediatric Compositions For Treating Multiple Sclerosis | NOVARTIS AG (CH) | 2016-07-21 | — | — | US | disclosed |
| EP-3011958-A1 | PAEDIATRIC COMPOSITIONS FOR TREATING MULTIPLE SCLEROSIS | Novartis AG (CH) | 2016-04-27 | — | — | EP | disclosed |
| US-20110152380-A1 | Paediatric Compositions For Treating Multiple Sclerosis | NOVARTIS AG (CH) | 2011-06-23 | — | — | US | disclosed |
| EP-2255798-A2 | Sphingosine-1-phosphate receptor agonists for use in the treatment of optic neuritis | Novartis AG (CH) | 2010-12-01 | — | — | EP | disclosed |
| EP-2251007-A2 | Sphingosine-1-phosphate (S1P) receptor agonists for use in the treatment of demyelinating diseases | Novartis AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| US-20090324542-A1 | optic neuritis; fingolimod or 2-amino-2-{2-[4-(1-oxo-5-phenylpentyl)phenyl]ethyl}propane-1,3-diol or salts as SP1 agonist | FOSTER CAROLYN ANN | 2009-12-31 | — | — | US | disclosed |
| US-20060046979-A1 | Combination therapy of sphingosine-1-phosphate (S1P) receptor agonist and coagent for treating demylination disease | FOSTER CAROLYN A | 2006-03-02 | — | — | US | disclosed |
| EP-1575576-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004028521-A2 | SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS IN THE TREATMENT OF DEMYELINATING DISORDERS | NOVARTIS AG (CH) | 2004-04-08 | — | — | WO | disclosed |
| US-20040014796-A1 | Novel compounds and compositions as cathepsin S inhititors | AXYS PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | disclosed |
| US-6492362-B1 | Compounds and compositions as cathepsin S inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117593-A1 | Paediatric Compositions for Treating Multiple Sclerosis | SMN1; SMN2, PMP22, CFTR | CTSS 2385/4885CTSB 1116/4885CTSK 1583/4885 |
| US-20090324542-A1 | optic neuritis; fingolimod or 2-amino-2-{2-[4-(1-oxo-5-phenylpentyl)phenyl]ethyl}propane-1,3-diol or salts as SP1 agonist | SP1, S1PR2, S1PR1 | CTSS 4227/4885CTSB 3963/4885CTSK 4692/4885 |
| US-20160206574-A1 | Paediatric Compositions For Treating Multiple Sclerosis | SMN1; SMN2, PMP22, CFTR | CTSS 2185/4885CTSB 986/4885CTSK 1420/4885 |
| US-20110152380-A1 | Paediatric Compositions For Treating Multiple Sclerosis | SMN1; SMN2, PMP22, CFTR | CTSS 2385/4885CTSB 1116/4885CTSK 1583/4885 |
| US-20170333368-A1 | Paediatric Compositions For Treating Multiple Sclerosis | SMN1; SMN2, PMP22, CFTR | CTSS 2266/4885CTSB 1079/4885CTSK 1565/4885 |
| US-20180177747-A1 | Paediatric Compositions For Treating Multiple Sclerosis | SMN1; SMN2, PMP22, CFTR | CTSS 2185/4885CTSB 986/4885CTSK 1420/4885 |
| US-20060046979-A1 | Combination therapy of sphingosine-1-phosphate (S1P) receptor agonist and coagent for treating demylination disease | S1PR1, S1PR4, S1PR2 | CTSS 1619/4885CTSB 1516/4885CTSK 2919/4885 |
| US-20200197334-A1 | Paediatric Compositions For Treating Multiple Sclerosis | SMN1; SMN2, PMP22, CFTR | CTSS 2185/4885CTSB 986/4885CTSK 1420/4885 |
| US-20170128389-A1 | Paediatric Compositions For Treating Multiple Sclerosis | SMN1; SMN2, PMP22, CFTR | CTSS 2185/4885CTSB 986/4885CTSK 1420/4885 |
| US-20040014796-A1 | Novel compounds and compositions as cathepsin S inhititors | CTSS, CTSB, CTSE | CTSS 1/4885CTSB 2/4885CTSK 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.