Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 5/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20927172 | 0.91 | LCK (0.36) | L3MBTL1LCKHDAC6ALDH1A1KDM4E | |
| SCHEMBL19899530 | 0.85 | L3MBTL1 (0.41) | L3MBTL1RAF1LCKTRPM8HDAC6 | |
| SCHEMBL19899715 | 0.84 | L3MBTL1 (0.41) | L3MBTL1RAF1LCKTRPM8HDAC6 | |
| SCHEMBL29450135 | 0.84 | L3MBTL1 (0.41) | L3MBTL1RAF1LCKTRPM8HDAC6 | |
| SCHEMBL15873244 | 0.78 | PIM1 (0.40) | L3MBTL1RAF1LCKATR | |
| SCHEMBL27866744 | 0.77 | ALDH1A1 (0.46) | L3MBTL1ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL18039588 | 0.76 | TRPM8 (0.42) | L3MBTL1LCKTRPM8ALDH1A1KDM4E | |
| SCHEMBL2520688 | 0.76 | USP30 (0.40) | LCKHDAC6ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2520080 | 0.76 | KMT2A (0.45) | LCKTRPM8KDM4ESMN1; SMN2 | |
| SCHEMBL2521682 | 0.76 | KDM4E (0.48) | L3MBTL1LCKTRPM8ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550117-B2 | 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use | GENENTECH, INC. (US) | 2020-02-04 | — | — | US | disclosed |
| US-20190119274-A1 | 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE | GENENTECH, INC. (US) | 2019-04-25 | — | — | US | disclosed |
| WO-2018037059-A1 | 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550117-B2 | 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use | NFKB2, NFKBIA, NFKB1 | L3MBTL1 2274/4885RAF1 848/4885LCK 1643/4885 |
| US-20190119274-A1 | 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE | NFKB2, NFKBIA, NFKB1 | L3MBTL1 2274/4885RAF1 848/4885LCK 1643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.