Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | CTH | P32929 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11515794 | 0.98 | RAB9A (0.64) | RAB9ALMNAALDH1A1POLBKDM4E | |
| SCHEMBL31675374 | 0.78 | RAB9A (0.61) | RAB9ALMNAALDH1A1POLBKDM4E | |
| SCHEMBL31675246 | 0.78 | RAB9A (0.61) | RAB9ALMNAALDH1A1POLBKDM4E | |
| SCHEMBL25373887 | 0.78 | RAB9A (0.61) | RAB9ALMNAALDH1A1POLBKDM4E | |
| SCHEMBL25373578 | 0.78 | RAB9A (0.61) | RAB9ALMNAALDH1A1POLBKDM4E | |
| SCHEMBL31675428 | 0.78 | RAB9A (0.61) | RAB9ALMNAALDH1A1POLBKDM4E | |
| SCHEMBL25373575 | 0.78 | RAB9A (0.61) | RAB9ALMNAALDH1A1POLBKDM4E | |
| Hydrochloric Acid SCHEMBL7526788 | 0.78 | RAB9A (0.97) | RAB9ALMNAALDH1A1POLBKDM4E | |
| SCHEMBL17509177 | 0.78 | RAB9A (0.39) | RAB9ALMNAALDH1A1POLBKDM4E | |
| SCHEMBL25373784 | 0.77 | RAB9A (0.59) | RAB9ALMNAALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12247027-B2 | P2X7 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2025-03-11 | — | — | US | disclosed |
| US-20240116930-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-04-11 | — | — | US | disclosed |
| US-11820770-B2 | P2X7 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-21 | — | — | US | disclosed |
| US-20220213095-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-07 | — | — | US | disclosed |
| US-11225478-B2 | P2X7 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-01-18 | — | — | US | disclosed |
| US-20200325138-A1 | P2X7 Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-10-15 | — | — | US | disclosed |
| US-10703749-B2 | P2X7 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-07-07 | — | — | US | disclosed |
| US-20190092770-A1 | P2X7 Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2019-03-28 | — | — | US | disclosed |
| US-10150765-B2 | P2X7 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-12-11 | — | — | US | disclosed |
| US-10112937-B2 | P2X7 modulators and methods of use | JANSSEN PHARMACEUTICA NV (BE) | 2018-10-30 | — | — | US | disclosed |
| US-20160376271-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV | 2016-12-29 | — | — | US | disclosed |
| US-9464084-B2 | P2X7 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2016-10-11 | — | — | US | disclosed |
| US-20160039809-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-11 | — | — | US | disclosed |
| US-20150322062-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-12 | — | — | US | disclosed |
| US-9066946-B2 | P2X7 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-06-30 | — | — | US | disclosed |
| US-20140275015-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-18 | — | — | US | disclosed |
| US-20110152313-A1 | SYNTHESIS OF AGELADINE A AND ANALOGS THEREOF | MACQUARIE UNIVERSITY (AU) | 2011-06-23 | — | — | US | disclosed |
| WO-2009152584-A1 | SYNTHESIS OF AGELADINE A AND ANALOGS THEREOF | MACQUARIE UNIVERSITY (AU) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200325138-A1 | P2X7 Modulators | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-10150765-B2 | P2X7 modulators | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-12247027-B2 | P2X7 modulators | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-20160376271-A1 | P2X7 MODULATORS | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-20190092770-A1 | P2X7 Modulators | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-11225478-B2 | P2X7 modulators | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-20110152313-A1 | SYNTHESIS OF AGELADINE A AND ANALOGS THEREOF | QDPR, ODC1, CROCC | RAB9A 114/4885LMNA 157/4885ALDH1A1 45/4885 |
| US-10112937-B2 | P2X7 modulators and methods of use | P2RX2, P2RX7, P2RX5 | RAB9A 3323/4885LMNA 2030/4885ALDH1A1 1385/4885 |
| US-20160039809-A1 | P2X7 MODULATORS | P2RX2, P2RX7, P2RX5 | RAB9A 3305/4885LMNA 2157/4885ALDH1A1 1381/4885 |
| US-20150322062-A1 | P2X7 MODULATORS | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-11820770-B2 | P2X7 modulators | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-20220213095-A1 | P2X7 MODULATORS | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-20240116930-A1 | P2X7 MODULATORS | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-10703749-B2 | P2X7 modulators | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
| US-20140275015-A1 | P2X7 MODULATORS | P2RX2, P2RX7, P2RY2 | RAB9A 3242/4885LMNA 2272/4885ALDH1A1 1628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.