Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19895548 | 0.89 | OPRL1 (0.44) | OPRL1CHRM4OPRM1OPRK1DRD4 | |
| SCHEMBL19895549 | 0.89 | OPRL1 (0.44) | OPRL1CHRM4OPRM1OPRK1DRD4 | |
| SCHEMBL9682087 | 0.78 | OPRL1 (0.44) | OPRL1CHRM4MAPTALDH1A1CYP2D6 | |
| SCHEMBL19895664 | 0.77 | CYP2D6 (0.42) | OPRL1OPRM1OPRK1LMNASMN1; SMN2 | |
| SCHEMBL19895635 | 0.77 | CYP2D6 (0.42) | OPRL1OPRM1OPRK1LMNASMN1; SMN2 | |
| SCHEMBL19895636 | 0.77 | CYP2D6 (0.42) | OPRL1OPRM1OPRK1LMNASMN1; SMN2 | |
| SCHEMBL844722 | 0.76 | LMNA (0.51) | OPRL1CHRM4DRD4LMNASMN1; SMN2 | |
| SCHEMBL6631278 | 0.76 | LMNA (0.51) | OPRL1CHRM4DRD4LMNASMN1; SMN2 | |
| SCHEMBL28454205 | 0.73 | SLC6A9 (0.50) | OPRL1OPRM1ALDH1A1CYP2D6 | |
| SCHEMBL23230699 | 0.71 | CACNA1A (0.47) | OPRL1OPRM1OPRK1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227349-B2 | Pyrazolo[1,5-a]pyrimidine compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-03-12 | — | — | US | disclosed |
| US-20180057499-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUND | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227349-B2 | Pyrazolo[1,5-a]pyrimidine compound | F2RL1, F2R, F2RL3 | OPRL1 1318/4885CHRM4 2903/4885OPRM1 1389/4885 |
| US-20180057499-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUND | DPYD, XDH, XPO5 | OPRL1 4178/4885CHRM4 4226/4885OPRM1 2305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.