Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TCF4 | P15884 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19132264 | 0.84 | KDM4E (0.54) | SCN10AAAK1ALDH1A1ALOX15HTT | |
| SCHEMBL26427165 | 0.80 | CYP1A2 (0.67) | SCN10AAAK1ALDH1A1ALOX15HTT | |
| SCHEMBL19132656 | 0.75 | DDAH1 (0.54) | ALDH1A1HTTMEN1KMT2ATCF4 | |
| SCHEMBL6367658 | 0.75 | SCN10A (0.41) | SCN10AALDH1A1ALOX15HTTMEN1 | |
| SCHEMBL1284420 | 0.74 | TAAR1 (0.59) | ALDH1A1KMT2AALPL | |
| SCHEMBL3813964 | 0.74 | MLKL (0.59) | SCN10AALDH1A1ALOX15HTTMEN1 | |
| SCHEMBL9263421 | 0.74 | KDM4E (0.71) | SCN10AAAK1ALDH1A1ALOX15HTT | |
| SCHEMBL23815820 | 0.73 | SCN10A (0.71) | SCN10AAAK1ALDH1A1ALOX15HTT | |
| SCHEMBL13996322 | 0.73 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2ATCF4CTNNB1 | |
| SCHEMBL13071044 | 0.72 | AAK1 (0.53) | SCN10AAAK1ALDH1A1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661425-B1 | HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES | CURIS INC (US) | 2018-02-28 | — | — | EP | disclosed |