Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221126 | 0.83 | PTGS2 (0.39) | IDO1ALDH1A1CA2 | |
| SCHEMBL3955245 | 0.81 | MAPT (0.35) | IDO1ALDH1A1MAPTCA2 | |
| SCHEMBL27645445 | 0.81 | MAOB (0.39) | IDO1KDM4E | |
| SCHEMBL193829 | 0.79 | LPL (0.35) | MAPTCA2 | |
| SCHEMBL2890983 | 0.78 | HTR7 (0.40) | KDM4EALDH1A1MAPTCA2 | |
| SCHEMBL2890570 | 0.78 | HRH3 (0.43) | ALDH1A1MAPT | |
| SCHEMBL193942 | 0.76 | — | — | |
| SCHEMBL7474811 | 0.76 | LTA4H (0.55) | CA2 | |
| SCHEMBL28893677 | 0.76 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTALOX15 | |
| SCHEMBL3960038 | 0.76 | PKM (0.37) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | claimed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |
| EP-0839133-B1 | 4,9-ETHANO-BENZO(F)ISOINDOLE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | RHONE POULENC RORER SA (FR) | 1999-10-06 | — | — | EP | disclosed |
| EP-0839133-A1 | 4,9-ETHANO-BENZO(F)ISOINDOLE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | Aventis Pharma S.A. (FR) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997003050-A1 | 4,9-ETHANO-BENZO(F)ISOINDOLE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | RHONE-POULENC RORER S.A. (FR) | 1997-01-30 | — | — | WO | disclosed |