Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917732 | 0.92 | TRPA1 (0.54) | TRPA1SRCOPRM1OPRL1BACE1 | |
| SCHEMBL19917775 | 0.88 | TRPA1 (0.44) | TRPA1SRCOPRM1OPRL1RORC | |
| SCHEMBL19917779 | 0.87 | TRPA1 (0.43) | TRPA1SRCOPRM1OPRL1RORC | |
| SCHEMBL19917724 | 0.82 | TRPA1 (0.55) | TRPA1 | |
| SCHEMBL19917669 | 0.82 | TRPA1 (0.43) | TRPA1BACE1MMP2MMP9MMP8 | |
| SCHEMBL19917704 | 0.81 | TRPA1 (0.50) | TRPA1SRCOPRM1OPRL1BACE1 | |
| SCHEMBL19917694 | 0.81 | TRPA1 (0.51) | TRPA1SRC | |
| SCHEMBL19917744 | 0.80 | TRPA1 (0.45) | TRPA1 | |
| SCHEMBL16894072 | 0.80 | TRPA1 (0.69) | TRPA1SRCOPRM1OPRL1BACE1 | |
| SCHEMBL19917690 | 0.80 | TRPA1 (0.43) | TRPA1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |