Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 13/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917686 | 0.87 | TRPA1 (0.53) | TRPA1OPRM1OPRL1RORCSRC | |
| SCHEMBL19917724 | 0.87 | TRPA1 (0.55) | TRPA1 | |
| SCHEMBL19917775 | 0.85 | TRPA1 (0.44) | TRPA1OPRM1OPRL1RORCSRC | |
| SCHEMBL19917702 | 0.82 | TRPA1 (0.53) | TRPA1 | |
| SCHEMBL16894188 | 0.81 | TRPA1 (0.57) | TRPA1KDM1AHDAC1OPRM1OPRL1 | |
| SCHEMBL19917780 | 0.81 | TRPA1 (0.43) | TRPA1KDM1AHDAC1OPRM1OPRL1 | |
| SCHEMBL19917732 | 0.79 | TRPA1 (0.54) | TRPA1OPRM1OPRL1RORCSRC | |
| SCHEMBL19917744 | 0.77 | TRPA1 (0.45) | TRPA1 | |
| SCHEMBL16965155 | 0.76 | TRPA1 (0.51) | TRPA1 | |
| SCHEMBL19917672 | 0.75 | CASR (0.42) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |