Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 9/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917744 | 0.93 | TRPA1 (0.45) | TRPA1PTGES | |
| SCHEMBL19917686 | 0.88 | TRPA1 (0.53) | TRPA1SRCOPRM1OPRL1RORC | |
| SCHEMBL19917779 | 0.85 | TRPA1 (0.43) | TRPA1SRCOPRM1OPRL1RORC | |
| SCHEMBL19917751 | 0.83 | TRPA1 (0.42) | TRPA1SRCPTGESWNT3A | |
| SCHEMBL19917728 | 0.81 | TRPA1 (0.46) | TRPA1SRCPTGES | |
| SCHEMBL19917773 | 0.81 | TRPA1 (0.45) | TRPA1SRCPTGESOPRM1OPRL1 | |
| SCHEMBL19917724 | 0.81 | TRPA1 (0.55) | TRPA1 | |
| SCHEMBL16894167 | 0.81 | TRPA1 (0.58) | TRPA1SRCPTGESHPGDSRORC | |
| SCHEMBL16964298 | 0.81 | TRPA1 (0.40) | TRPA1SRCPTGES | |
| SCHEMBL19917732 | 0.81 | TRPA1 (0.54) | TRPA1SRCOPRM1OPRL1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |