Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 11/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917700 | 0.90 | TRPA1 (0.40) | TRPA1SYKPTGESPOLBMEN1 | |
| SCHEMBL19917730 | 0.90 | TRPA1 (0.44) | TRPA1SYK | |
| SCHEMBL16894082 | 0.84 | TRPA1 (0.51) | TRPA1PTGESMEN1KMT2A | |
| SCHEMBL19917706 | 0.82 | TRPA1 (0.38) | TRPA1SYKPTGES | |
| SCHEMBL19917743 | 0.78 | TRPA1 (0.45) | TRPA1PTGESMEN1KMT2A | |
| SCHEMBL19917662 | 0.77 | TRPA1 (0.43) | TRPA1SYKPOLBMEN1KMT2A | |
| SCHEMBL19917773 | 0.76 | TRPA1 (0.45) | TRPA1PTGESPOLBMEN1KMT2A | |
| SCHEMBL16894125 | 0.76 | TRPA1 (0.63) | TRPA1 | |
| SCHEMBL16894123 | 0.75 | TRPA1 (0.49) | TRPA1PTGESMEN1KMT2APTGER1 | |
| SCHEMBL19917696 | 0.75 | TRPA1 (0.48) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |