Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 3/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917743 | 0.93 | TRPA1 (0.45) | TRPA1WNT3APTGESMEN1KMT2A | |
| SCHEMBL19917687 | 0.88 | TRPA1 (0.54) | TRPA1SRCOPRM1OPRL1ALDH1A1 | |
| SCHEMBL19917780 | 0.84 | TRPA1 (0.43) | TRPA1SRCOPRM1OPRL1ALDH1A1 | |
| SCHEMBL16894167 | 0.82 | TRPA1 (0.58) | TRPA1SRCPTGES | |
| SCHEMBL19917752 | 0.81 | TRPA1 (0.41) | TRPA1SRCOPRM1OPRL1ALDH1A1 | |
| SCHEMBL19917775 | 0.81 | TRPA1 (0.44) | TRPA1SRCOPRM1OPRL1WNT3A | |
| SCHEMBL19917725 | 0.81 | TRPA1 (0.54) | TRPA1OPRM1OPRL1 | |
| SCHEMBL19917730 | 0.81 | TRPA1 (0.44) | TRPA1SRCALDH1A1 | |
| SCHEMBL19917733 | 0.80 | TRPA1 (0.55) | TRPA1SRCOPRM1OPRL1ALDH1A1 | |
| SCHEMBL19917781 | 0.80 | TRPA1 (0.41) | TRPA1SRCOPRM1OPRL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |