Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 9/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917700 | 0.88 | TRPA1 (0.40) | TRPA1GAAMAPTLMNASYK | |
| SCHEMBL19917730 | 0.87 | TRPA1 (0.44) | TRPA1TP53MAPTLMNARXFP1 | |
| SCHEMBL19917743 | 0.86 | TRPA1 (0.45) | TRPA1TP53MEN1KMT2A | |
| SCHEMBL16894173 | 0.84 | TRPA1 (0.61) | TRPA1 | |
| SCHEMBL19917733 | 0.83 | TRPA1 (0.55) | TRPA1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL19917661 | 0.83 | TRPA1 (0.43) | TRPA1TP53GAATRPC5MAPT | |
| SCHEMBL19917696 | 0.83 | TRPA1 (0.48) | TRPA1LMNAALDH1A1 | |
| SCHEMBL19917783 | 0.79 | TRPA1 (0.51) | TRPA1 | |
| SCHEMBL19917773 | 0.78 | TRPA1 (0.45) | TRPA1ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL19917707 | 0.77 | TRPA1 (0.40) | TRPA1SYKMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |