Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | STAMBP | O95630 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917781 | 0.90 | TRPA1 (0.41) | TRPA1LMNACCR1TDP1PTGES | |
| SCHEMBL19917743 | 0.89 | TRPA1 (0.45) | TRPA1CCR1TDP1PTGESTP53 | |
| SCHEMBL19917705 | 0.87 | TRPA1 (0.51) | TRPA1LMNATP53SRCL3MBTL1 | |
| SCHEMBL16894139 | 0.83 | TRPA1 (0.47) | TRPA1LMNATDP1 | |
| SCHEMBL19917751 | 0.83 | TRPA1 (0.42) | TRPA1CCR1TDP1PTGESSRC | |
| SCHEMBL19917773 | 0.81 | TRPA1 (0.45) | TRPA1PTGESSRCP2RX7L3MBTL1 | |
| SCHEMBL16894136 | 0.80 | TRPA1 (0.60) | TRPA1 | |
| SCHEMBL16894174 | 0.80 | ALDH1A1 (0.52) | TRPA1ALDH1A1 | |
| SCHEMBL19917744 | 0.80 | TRPA1 (0.45) | TRPA1CCR1TDP1PTGESP2RX7 | |
| SCHEMBL16964298 | 0.80 | TRPA1 (0.40) | TRPA1CCR1TDP1PTGESSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |