Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 14/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917760 | 0.87 | TRPA1 (0.46) | TRPA1LMNADDR1PPARDKIF11 | |
| SCHEMBL19917733 | 0.86 | TRPA1 (0.55) | TRPA1LMNAPTGER1 | |
| SCHEMBL19917776 | 0.86 | TRPA1 (0.45) | TRPA1LMNADDR1PPARDKIF11 | |
| SCHEMBL19917673 | 0.85 | CASR (0.42) | TRPA1LMNAPTGER1 | |
| SCHEMBL19917670 | 0.85 | TRPA1 (0.44) | TRPA1LMNAPTGER1 | |
| SCHEMBL19917691 | 0.83 | KDM1A (0.45) | TRPA1LMNAPTGER1 | |
| SCHEMBL19917716 | 0.81 | TRPA1 (0.41) | TRPA1LMNA | |
| SCHEMBL16894090 | 0.81 | TRPA1 (0.57) | TRPA1 | |
| SCHEMBL19917755 | 0.80 | TRPA1 (0.47) | TRPA1TRPV1 | |
| SCHEMBL16894260 | 0.79 | KMT2A (0.57) | TRPA1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |