Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917687 | 0.92 | TRPA1 (0.54) | TRPA1BACE1CASRSRCOPRM1 | |
| SCHEMBL19917670 | 0.90 | TRPA1 (0.44) | TRPA1BACE1OPRM1OPRL1LMNA | |
| SCHEMBL19917743 | 0.88 | TRPA1 (0.45) | TRPA1MEN1KMT2A | |
| SCHEMBL19917705 | 0.88 | TRPA1 (0.51) | TRPA1BACE1CASRSRCOPRM1 | |
| SCHEMBL19917691 | 0.87 | KDM1A (0.45) | TRPA1OPRM1OPRL1ALDH1A1LMNA | |
| SCHEMBL19917696 | 0.86 | TRPA1 (0.48) | TRPA1SRCALDH1A1LMNA | |
| SCHEMBL19917673 | 0.86 | CASR (0.42) | TRPA1CASROPRM1OPRL1LMNA | |
| SCHEMBL19917756 | 0.86 | TRPA1 (0.46) | TRPA1LMNAPTGER1 | |
| SCHEMBL19917716 | 0.86 | TRPA1 (0.41) | TRPA1CASRALDH1A1LMNAPOLB | |
| SCHEMBL19917662 | 0.83 | TRPA1 (0.43) | TRPA1ALDH1A1LMNAMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |