Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917776 | 0.88 | TRPA1 (0.45) | TRPA1LMNADDR1KIF11PPARD | |
| SCHEMBL19917756 | 0.87 | TRPA1 (0.46) | TRPA1LMNADDR1KIF11PPARD | |
| SCHEMBL19917761 | 0.86 | LMNA (0.53) | LMNAKMT2AOPRM1OPRL1HPGD | |
| SCHEMBL19917705 | 0.85 | TRPA1 (0.51) | TRPA1LMNAOPRM1OPRL1 | |
| SCHEMBL19917766 | 0.84 | LMNA (0.44) | TRPA1LMNAKMT2AOPRM1OPRL1 | |
| SCHEMBL19917770 | 0.82 | LMNA (0.38) | TRPA1LMNADDR1KMT2AOPRM1 | |
| SCHEMBL16894260 | 0.81 | KMT2A (0.57) | TRPA1KMT2AGAA | |
| SCHEMBL19917765 | 0.81 | TRPA1 (0.47) | TRPA1KIF11PPARDPOLQKMT2A | |
| SCHEMBL19917754 | 0.80 | MAPT (0.42) | TRPA1LMNAKMT2AGAAHPGD | |
| SCHEMBL19917757 | 0.79 | TRPA1 (0.54) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |