Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 8/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917716 | 0.90 | TRPA1 (0.41) | TRPA1TACR1CCR2LMNARXRA | |
| SCHEMBL19917733 | 0.90 | TRPA1 (0.55) | TRPA1LMNABACE1OPRM1OPRL1 | |
| SCHEMBL19917691 | 0.88 | KDM1A (0.45) | TRPA1TACR1CCR2LMNAOPRM1 | |
| SCHEMBL19917783 | 0.87 | TRPA1 (0.51) | TRPA1 | |
| SCHEMBL19917655 | 0.86 | LMNA (0.40) | TRPA1TACR1CCR2LMNABACE1 | |
| SCHEMBL19917673 | 0.85 | CASR (0.42) | TRPA1LMNAOPRM1OPRL1PPARA | |
| SCHEMBL19917756 | 0.85 | TRPA1 (0.46) | TRPA1LMNAPTGER1 | |
| SCHEMBL19917692 | 0.82 | CASR (0.57) | TRPA1PPARA | |
| SCHEMBL19917687 | 0.81 | TRPA1 (0.54) | TRPA1BACE1OPRM1OPRL1NPC1 | |
| SCHEMBL16894134 | 0.81 | TRPA1 (0.57) | TRPA1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |