Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917705 | 0.90 | TRPA1 (0.51) | LMNANPC1RAB9AOPRM1OPRL1 | |
| SCHEMBL19917766 | 0.89 | LMNA (0.44) | LMNANPC1RAB9APOLBLSS | |
| SCHEMBL19917729 | 0.87 | LMNA (0.48) | LMNANPC1RAB9APOLBLSS | |
| SCHEMBL19917760 | 0.86 | TRPA1 (0.46) | LMNAHPGDOPRM1OPRL1KMT2A | |
| SCHEMBL19917754 | 0.86 | MAPT (0.42) | LMNAPOLBHPGDKMT2AMEN1 | |
| SCHEMBL19917770 | 0.83 | LMNA (0.38) | LMNAOPRM1OPRL1KMT2AMEN1 | |
| SCHEMBL19917757 | 0.81 | TRPA1 (0.54) | — | |
| SCHEMBL19917762 | 0.79 | NPC1 (0.46) | LMNANPC1RAB9ALSSHPGD | |
| SCHEMBL16894115 | 0.79 | TDP1 (0.55) | KMT2AALDH1A1 | |
| SCHEMBL19917752 | 0.79 | TRPA1 (0.41) | LMNAOPRM1OPRL1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |