Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 11/20 | 0.46 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917765 | 0.90 | TRPA1 (0.47) | TRPA1PPARDKIF11 | |
| SCHEMBL19917731 | 0.88 | NPC1 (0.43) | TRPA1PTGER1PPARA | |
| SCHEMBL19917755 | 0.87 | TRPA1 (0.47) | TRPA1 | |
| SCHEMBL19917688 | 0.85 | CASR (0.38) | TRPA1PTGER1PPARA | |
| SCHEMBL19917653 | 0.85 | TRPA1 (0.38) | TRPA1PTGER1PPARA | |
| SCHEMBL19917763 | 0.83 | BACE1 (0.52) | TRPA1 | |
| SCHEMBL19917735 | 0.81 | TRPA1 (0.40) | TRPA1PPARD | |
| SCHEMBL16894100 | 0.80 | TRPA1 (0.54) | TRPA1PTGER1 | |
| SCHEMBL19917776 | 0.79 | TRPA1 (0.45) | TRPA1PPARDBCHEKIF11PPARA | |
| SCHEMBL16894260 | 0.78 | KMT2A (0.57) | TRPA1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |