Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.31 |
| ▸ | TEK | Q02763 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30452407 | 0.68 | TSHR (0.39) | ALDH1A1ALOX15MAPK1 | |
| SCHEMBL7873757 | 0.68 | ALDH1A1 (0.41) | KMT2AMAPTMEN1POLBEPHB4 | |
| SCHEMBL7821197 | 0.67 | KMT2A (0.44) | KMT2AGAAMAPTMEN1POLB | |
| SCHEMBL11872403 | 0.67 | KMT2A (0.50) | KMT2AGAAMAPTMEN1POLB | |
| SCHEMBL19918137 | 0.63 | GAA (0.32) | KMT2AGAAMAPTMEN1POLB | |
| SCHEMBL29240011 | 0.62 | — | — | |
| SCHEMBL1727586 | 0.62 | — | — | |
| SCHEMBL4375871 | 0.62 | RAB9A (0.55) | KMT2AMAPTMEN1POLBALDH1A1 | |
| SCHEMBL29037561 | 0.61 | TSHR (0.36) | MAPTALDH1A1MAPK1 | |
| Bromide SCHEMBL4449401 | 0.61 | ZDHHC20 (0.47) | ALDH1A1L3MBTL1LMNAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367798-B1 | PYRAZOLONE DERIVATIVES USEFUL IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | UNIV NORTHWESTERN (US) | 2018-02-28 | — | — | EP | disclosed |