Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 3/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 13/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28610633 | 0.86 | PRMT6 (0.63) | ITGB3ITGA2BPRMT6 | |
| SCHEMBL30799020 | 0.82 | SLC6A4 (0.58) | SIGMAR1CHRM3 | |
| SCHEMBL4176561 | 0.82 | SLC6A4 (0.58) | SIGMAR1CHRM3 | |
| SCHEMBL21961925 | 0.82 | SIGMAR1 (0.71) | SIGMAR1PRMT6 | |
| SCHEMBL1259602 | 0.82 | SIGMAR1 (0.71) | SIGMAR1PRMT6 | |
| Bromide SCHEMBL1259195 | 0.81 | SIGMAR1 (0.69) | SIGMAR1PRMT6 | |
| Hydrochloric Acid SCHEMBL4576942 | 0.81 | GLS (0.54) | GLSSIGMAR1CHRM3 | |
| SCHEMBL21799527 | 0.80 | PRMT6 (0.72) | GLSSIGMAR1CHRM3PRMT6 | |
| Urea SCHEMBL6942597 | 0.80 | SIGMAR1 (0.79) | SIGMAR1 | |
| SCHEMBL15855008 | 0.79 | SIGMAR1 (0.58) | GLSSIGMAR1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277276-B1 | METHODS OF ADMINISTERING GLUTAMINASE INHIBITORS | CALITHERA BIOSCIENCES INC (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018039442-A1 | TREATMENT OF CANCER WITH INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES, INC. (US) | 2018-03-01 | — | — | WO | disclosed |