Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 5/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495171 | 0.84 | ALDH1A1 (0.40) | ALDH1A1SIGMAR1L3MBTL1HTTRAB9A | |
| SCHEMBL4202588 | 0.75 | L3MBTL1 (0.35) | ALDH1A1SIGMAR1L3MBTL1HTTRAB9A | |
| SCHEMBL4202678 | 0.75 | L3MBTL1 (0.35) | ALDH1A1SIGMAR1L3MBTL1HTTRAB9A | |
| SCHEMBL21400923 | 0.75 | SIGMAR1 (0.36) | ALDH1A1SIGMAR1L3MBTL1HTT | |
| SCHEMBL15652741 | 0.72 | ALDH1A1 (0.33) | ALDH1A1SIGMAR1L3MBTL1 | |
| SCHEMBL290078 | 0.71 | ALDH1A1 (0.34) | ALDH1A1SIGMAR1L3MBTL1HTT | |
| SCHEMBL290079 | 0.71 | ADH1A (0.39) | ALDH1A1SIGMAR1L3MBTL1HTT | |
| SCHEMBL9874179 | 0.70 | SIGMAR1 (0.34) | ALDH1A1SIGMAR1 | |
| SCHEMBL14155721 | 0.68 | BCHE (0.41) | ALDH1A1SIGMAR1L3MBTL1HTTRAB9A | |
| SCHEMBL12521647 | 0.68 | BCHE (0.41) | ALDH1A1SIGMAR1L3MBTL1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504210-A1 | 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | H. Hoffnabb-La Roche Ag (CH) | 2019-07-03 | — | — | EP | disclosed |
| WO-2018041763-A1 | 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-08 | — | — | WO | disclosed |