Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RARB | P10826 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20569880 | 0.75 | ADA (0.34) | KDM5A | |
| SCHEMBL24853072 | 0.72 | HCAR3 (0.46) | MAPK1HCAR3KMT2ARARBMAPT | |
| SCHEMBL27735557 | 0.71 | NPC1 (0.38) | KMT2AHPGD | |
| SCHEMBL15559838 | 0.71 | TSHR (0.39) | MAPK1HCAR3KMT2AHPGDKDM5A | |
| SCHEMBL24035819 | 0.68 | HCAR3 (0.35) | MAPK1HCAR3KMT2AHPGDKDM5A | |
| SCHEMBL18696360 | 0.65 | TSHR (0.39) | — | |
| SCHEMBL24724722 | 0.64 | NPC1 (0.41) | HCAR3KMT2AKDM5AKDM4CKDM5B | |
| SCHEMBL22748596 | 0.63 | ALDH1A1 (0.41) | KMT2ARARBMAPT | |
| SCHEMBL29132918 | 0.62 | HCAR3 (0.37) | HCAR3KMT2AKDM4CMAPT | |
| SCHEMBL5828562 | 0.61 | HCAR3 (0.37) | HCAR3KMT2AHPGDKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433480-A1 | HETEROCYCLIC NLRP3 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2024-09-25 | — | — | EP | disclosed |
| WO-2023088856-A1 | HETEROCYCLIC NLRP3 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-05-25 | — | — | WO | disclosed |
| EP-3507290-A1 | INHIBITORS OF CELLULAR METABOLIC PROCESSES | Agios Pharmaceuticals, Inc. (US) | 2019-07-10 | — | — | EP | disclosed |
| WO-2018045071-A1 | INHIBITORS OF CELLULAR METABOLIC PROCESSES | AGIOS PHARMACEUTICALS, INC. (US) | 2018-03-08 | — | — | WO | disclosed |