Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22608005 | 1.00 | MAP4K4 (0.48) | MAP4K4F10BTKJAK3AURKA | |
| SCHEMBL19934557 | 0.91 | MAP4K4 (0.47) | MAP4K4F10BTKJAK3AURKA | |
| SCHEMBL29727404 | 0.91 | MAP4K4 (0.47) | MAP4K4F10BTKJAK3AURKA | |
| SCHEMBL22621256 | 0.91 | MAP4K4 (0.47) | MAP4K4F10BTKJAK3AURKA | |
| SCHEMBL22621309 | 0.88 | F10 (0.47) | MAP4K4F10BTKJAK3AURKA | |
| SCHEMBL29727403 | 0.88 | F10 (0.47) | MAP4K4F10BTKJAK3AURKA | |
| SCHEMBL19934556 | 0.88 | F10 (0.47) | MAP4K4F10BTKJAK3AURKA | |
| SCHEMBL13713228 | 0.85 | PIM1 (0.43) | MAP4K4F10BTKJAK3CA1 | |
| SCHEMBL19926359 | 0.83 | MAP4K4 (0.52) | MAP4K4F10BTKJAK3AURKA | |
| SCHEMBL28307851 | 0.83 | MAP4K4 (0.52) | MAP4K4F10BTKJAK3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109923107-B | Process for preparing indole carboxamide compounds | 百时美施贵宝公司 | 2022-06-14 | — | — | CN | disclosed |
| US-11220489-B2 | Process for preparing indole carboxamide compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-01-11 | — | — | US | disclosed |
| US-20210276970-A1 | PROCESS FOR PREPARING INDOLE CARBOXAMIDE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-09 | — | — | US | disclosed |
| EP-3507282-B1 | PROCESS FOR PREPARING INDOLE CARBOXAMIDE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-3507282-A1 | PROCESS FOR PREPARING INDOLE CARBOXAMIDE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2019-07-10 | — | — | EP | disclosed |
| WO-2018045157-A1 | PROCESS FOR PREPARING INDOLE CARBOXAMIDE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210276970-A1 | PROCESS FOR PREPARING INDOLE CARBOXAMIDE COMPOUNDS | TPH2, TPH1, IDO2 | MAP4K4 679/4885F10 2535/4885BTK 1850/4885 |
| US-11220489-B2 | Process for preparing indole carboxamide compounds | TPH2, TPH1, IDO2 | MAP4K4 679/4885F10 2535/4885BTK 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.