Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19923181 | 0.81 | SLC6A3 (0.59) | ALDH1A1SLC6A3SLC6A4LMNAKDM4E | |
| SCHEMBL5536756 | 0.80 | ALDH1A1 (0.55) | ALDH1A1LMNAKDM4EKMT2AMAPK10 | |
| SCHEMBL19929648 | 0.79 | MRGPRX4 (0.45) | ALDH1A1SLC6A3SLC6A4LMNAKDM4E | |
| SCHEMBL1963803 | 0.74 | LMNA (0.51) | ALDH1A1SLC6A3SLC6A4LMNAKDM4E | |
| SCHEMBL17249874 | 0.73 | MAPK10 (0.41) | ALDH1A1LMNAKDM4EKMT2AMAPK10 | |
| SCHEMBL28409134 | 0.73 | TSHR (0.61) | ALDH1A1SLC6A3SLC6A4LMNAKDM4E | |
| SCHEMBL16955180 | 0.72 | LMNA (0.49) | ALDH1A1SLC6A3SLC6A4LMNAKDM4E | |
| SCHEMBL5538272 | 0.72 | ALDH1A1 (0.60) | ALDH1A1LMNAKDM4EKMT2AHTT | |
| SCHEMBL29109366 | 0.71 | SLC6A3 (0.64) | ALDH1A1SLC6A3SLC6A4LMNAKDM4E | |
| SCHEMBL2192561 | 0.71 | ALDH1A1 (0.47) | ALDH1A1SLC6A3SLC6A4LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180065917-A1 | IMMUNE CHECKPOINT INHIBITORS, COMPOSITIONS AND METHODS THEREOF | POLARIS PHARMACEUTICALS, INC. (JP) | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180065917-A1 | IMMUNE CHECKPOINT INHIBITORS, COMPOSITIONS AND METHODS THEREOF | CD274, PDCD1, PDCD1LG2 | ALDH1A1 817/4885SLC6A3 3277/4885SLC6A4 3872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.