Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10049092 | 0.86 | CRHR1 (0.42) | CRHR1HSP90AA1HSP90AB1GRM5ADORA2B | |
| SCHEMBL19936685 | 0.77 | CRHR1 (0.41) | CRHR1HSP90AA1HSP90AB1ADORA2B | |
| SCHEMBL19936632 | 0.76 | HSP90AA1 (0.45) | CRHR1HSP90AA1HSP90AB1GRM5ADORA2B | |
| SCHEMBL19936384 | 0.76 | CRHR1 (0.40) | CRHR1HSP90AA1HSP90AB1ADORA2B | |
| SCHEMBL3435623 | 0.75 | MARS1 (0.53) | — | |
| SCHEMBL14805149 | 0.72 | NPC1 (0.50) | — | |
| SCHEMBL3436287 | 0.72 | MARS1 (0.44) | CRHR1HSP90AA1HSP90AB1GRM5ADORA2B | |
| SCHEMBL3436423 | 0.71 | CA1 (0.41) | CRHR1 | |
| SCHEMBL10049094 | 0.70 | CA1 (0.43) | GRM5 | |
| SCHEMBL27934982 | 0.70 | HSD11B1 (0.46) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |