Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pyrophosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA5A | P35218 | 2/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.35 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrophosphoric Acid SCHEMBL2113857 | 0.97 | FDPS (0.71) | FDPSBLMTDP1SLC34A1KDM4E | |
| Pyrophosphoric Acid SCHEMBL5575855 | 0.97 | FDPS (0.71) | FDPSBLMTDP1SLC34A1KDM4E | |
| Pyrophosphoric Acid SCHEMBL27132925 | 0.93 | FDPS (0.67) | FDPSBLMTDP1SLC34A1KDM4E | |
| Pyrophosphoric Acid SCHEMBL28978110 | 0.93 | FDPS (0.67) | FDPSBLMTDP1SLC34A1KDM4E | |
| Pyrophosphoric Acid SCHEMBL28511969 | 0.93 | FDPS (0.67) | FDPSBLMTDP1SLC34A1KDM4E | |
| Pyrophosphoric Acid SCHEMBL28833809 | 0.90 | FDPS (0.62) | FDPSBLMTDP1SLC34A1KDM4E | |
| Pyrophosphoric Acid SCHEMBL3906363 | 0.90 | FDPS (0.62) | FDPSBLMTDP1SLC34A1KDM4E | |
| Pyrophosphoric Acid SCHEMBL31539936 | 0.90 | FDPS (0.62) | FDPSBLMTDP1SLC34A1KDM4E | |
| Pyrophosphoric Acid SCHEMBL28706087 | 0.90 | FDPS (0.62) | FDPSBLMTDP1SLC34A1KDM4E | |
| Pyrophosphoric Acid SCHEMBL9400188 | 0.90 | FDPS (0.71) | FDPSBLMTDP1SLC34A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130202713-A1 | COATING OF PARTICLES COMPRISING A PHARMACEUTICALLY ACTIVE INGREDIENT WITH A CARBONATE SALT OR PHOSPHATE SALT | LEK PHARMACEUTICALS D.D. (SI) | 2013-08-08 | — | — | US | disclosed |
| US-20130115301-A1 | COATING OF PARTICLES COMPRISING A PHARMACEUTICALLY ACTIVE INGREDIENT WITH A CARBONATE SALT OR PHOSPHATE SALT | JAMNIK, Janko (SI) | 2013-05-09 | — | — | US | disclosed |
| EP-2515885-A1 | COATING OF PARTICLES COMPRISING A PHARMACEUTICALLY ACTIVE INGREDIENT WITH A CARBONATE SALT OR PHOSPHATE SALT | LEK Pharmaceuticals d.d. (SI) | 2012-10-31 | — | — | EP | disclosed |
| EP-2515884-A1 | COATING OF PARTICLES COMPRISING A PHARMACEUTICALLY ACTIVE INGREDIENT WITH A CARBONATE SALT OR PHOSPHATE SALT | LEK Pharmaceuticals d.d. (SI) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076743-A1 | COATING OF PARTICLES COMPRISING A PHARMACEUTICALLY ACTIVE INGREDIENT WITH A CARBONATE SALT OR PHOSPHATE SALT | LEK PHARMACEUTICALS D.D. (SI) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011076738-A1 | COATING OF PARTICLES COMPRISING A PHARMACEUTICALLY ACTIVE INGREDIENT WITH A CARBONATE SALT OR PHOSPHATE SALT | LEK PHARMACEUTICALS D.D. (SI) | 2011-06-30 | — | — | WO | disclosed |
| EP-2338480-A1 | Coating of particles comprising a pharmaceutically active ingredient with a carbonate salt or phosphate salt | LEK Pharmaceuticals d.d. (SI) | 2011-06-29 | — | — | EP | disclosed |