SCHEMBL19948600

SCHEMBL19948600

O=C(O)N1C[C@H]2CC[C@@H](C1)N2

nearest known ligand 0.61

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 20/20 0.61
CHRNA3 P32297 20/20 0.61
CHRNA4 P43681 20/20 0.61
CHRNB3 Q05901 20/20 0.61
CHRNA6 Q15825 20/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1404444 1.00 CHRNB2 (0.61) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Hydrochloric Acid SCHEMBL5965871 0.98 CHRNB2 (0.59) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Hydrochloric Acid SCHEMBL7006653 0.95 CHRNB2 (0.57) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL30260009 0.91 CHRNB2 (0.53) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL1588528 0.91 CHRNB2 (0.53) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL30259987 0.91 CHRNB2 (0.53) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL18705654 0.87 CHRNB2 (0.62) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL20186613 0.87 CHRNB2 (0.53) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL20186616 0.87 CHRNB2 (0.53) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL30259993 0.81 CHRNB2 (0.45) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4363412-A1 SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT Dana-Farber Cancer Institute, Inc. (US) 2024-05-08 EP disclosed
US-20240101553-A1 KRAS G12C INHIBITORS MIRATI THERAPEUTICS INC (US) 2024-03-28 US disclosed
US-20240059710-A1 KRAS G12D Inhibitors JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2024-02-22 US disclosed
US-20240059674-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-02-22 US disclosed
US-20240025918-A1 KRAS G12D Inhibitors JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2024-01-25 US disclosed
WO-2023244764-A1 COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 C4 THERAPEUTICS, INC. (US) 2023-12-21 WO disclosed
EP-4291199-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF Kumquat Biosciences Inc. (US) 2023-12-20 EP disclosed
US-20230373999-A1 KRAS G12C INHIBITORS MIRATI THERAPEUTICS INC (US) 2023-11-23 US disclosed
US-20230303509-A1 SULFONAMIDO DERIVATIVES AS CYCLIN-DEPENDENT KINASE 2 INHIBITORS NIKANG THERAPEUTICS, INC. 2023-09-28 US disclosed
US-20230212122-A1 MITOCHONDRIAL TARGETING COMPOUNDS FOR THE TREATMENT OF ASSOCIATED DISEASES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2023-07-06 US disclosed
WO-2020264499-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2020-12-30 WO disclosed
EP-3383853-B1 HOMOBISPIPERIDINYL DERIVATIVES AS LIVER X RECEPTOR (LXR) BETA AGONISTS FOR TREATING E.G. ALZHEIMER'S DISEASE MERCK SHARP & DOHME (US) 2020-11-04 EP disclosed
US-10752587-B2 Homobispiperidinyl derivatives as liver X receptor beta agonists, compositions and their use MERCK SHARP & DOHME CORP. (US) 2020-08-25 US disclosed
US-20200262837-A1 KRAS G12C INHIBITORS ARRAY BIOPHARMA INC. 2020-08-20 US disclosed
US-10689377-B2 KRas G12C inhibitors Mirati Therapeutics, Inc. (US) 2020-06-23 US disclosed
US-10633381-B2 KRas G12C inhibitors Mirati Therapeutics, Inc. (US) 2020-04-28 US disclosed
US-20190144444-A1 KRAS G12C INHIBITORS Mirati Therapeutics, Inc. 2019-05-16 US disclosed
US-20180354901-A1 HOMOBISPIPERIDINYL DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS AND THEIR USE MERCK SHARP & DOHME CORP. (US) 2018-12-13 US disclosed
US-10125134-B2 KRas G12C inhibitors Mirati Therapeutics, Inc. (US) 2018-11-13 US disclosed
US-20180072723-A1 KRAS G12C INHIBITORS Mirati Therapeutics, Inc. 2018-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190144444-A1 KRAS G12C INHIBITORS KRAS, NRAS, HRAS CHRNB2 4856/4885CHRNA3 4866/4885CHRNA4 4878/4885
US-20240059710-A1 KRAS G12D Inhibitors KRAS, NRAS, HRAS CHRNB2 4837/4885CHRNA3 4866/4885CHRNA4 4882/4885
US-10633381-B2 KRas G12C inhibitors KRAS, NRAS, HRAS CHRNB2 4856/4885CHRNA3 4866/4885CHRNA4 4878/4885
US-20200262837-A1 KRAS G12C INHIBITORS KRAS, NRAS, HRAS CHRNB2 4856/4885CHRNA3 4866/4885CHRNA4 4878/4885
US-20230303509-A1 SULFONAMIDO DERIVATIVES AS CYCLIN-DEPENDENT KINASE 2 INHIBITORS CDK2, CCNK, CCNI CHRNB2 4818/4885CHRNA3 4883/4885CHRNA4 4885/4885
US-10125134-B2 KRas G12C inhibitors KRAS, NRAS, HRAS CHRNB2 4856/4885CHRNA3 4866/4885CHRNA4 4878/4885
US-10752587-B2 Homobispiperidinyl derivatives as liver X receptor beta agonists, compositions and their use NR1H2, NR1H3, NR1H4 CHRNB2 185/4885CHRNA3 215/4885CHRNA4 235/4885
US-10689377-B2 KRas G12C inhibitors KRAS, NRAS, HRAS CHRNB2 4856/4885CHRNA3 4866/4885CHRNA4 4878/4885
US-20240101553-A1 KRAS G12C INHIBITORS KRAS, NRAS, HRAS CHRNB2 4856/4885CHRNA3 4866/4885CHRNA4 4878/4885
US-20180354901-A1 HOMOBISPIPERIDINYL DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS AND THEIR USE NR1H2, NR1H3, NR1H4 CHRNB2 185/4885CHRNA3 215/4885CHRNA4 235/4885
US-20240059674-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 CHRNB2 4503/4885CHRNA3 4431/4885CHRNA4 4510/4885
US-20180072723-A1 KRAS G12C INHIBITORS KRAS, NRAS, HRAS CHRNB2 4856/4885CHRNA3 4866/4885CHRNA4 4878/4885
US-20230212122-A1 MITOCHONDRIAL TARGETING COMPOUNDS FOR THE TREATMENT OF ASSOCIATED DISEASES TFAM, CS, FH CHRNB2 4127/4885CHRNA3 4535/4885CHRNA4 4532/4885
US-20240025918-A1 KRAS G12D Inhibitors KRAS, NRAS, HRAS CHRNB2 4859/4885CHRNA3 4863/4885CHRNA4 4883/4885
US-20230373999-A1 KRAS G12C INHIBITORS KRAS, NRAS, HRAS CHRNB2 4856/4885CHRNA3 4866/4885CHRNA4 4878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.