Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.45 |
| ▸ | KIT | P10721 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 5/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951623 | 0.78 | MAP4K1 (0.45) | MAP4K1NTRK1KITFLT3 | |
| SCHEMBL19949930 | 0.77 | MAP4K1 (0.44) | MAP4K1NTRK1KITFLT3KDM4E | |
| SCHEMBL19964796 | 0.74 | MAP4K1 (0.42) | MAP4K1NTRK1KITFLT3KDM4E | |
| SCHEMBL19951650 | 0.73 | ALDH1A1 (0.52) | MAP4K1NTRK1KITFLT3KDM4E | |
| SCHEMBL28905423 | 0.71 | MAP4K1 (0.54) | MAP4K1NTRK1KITFLT3 | |
| SCHEMBL30032035 | 0.71 | MAP4K1 (0.54) | MAP4K1NTRK1KITFLT3 | |
| SCHEMBL20791776 | 0.69 | MAP4K1 (0.51) | MAP4K1NTRK1KITFLT3 | |
| SCHEMBL19949984 | 0.69 | MAP4K1 (0.69) | MAP4K1NTRK1KITFLT3 | |
| SCHEMBL29746585 | 0.69 | MAP4K1 (0.69) | MAP4K1NTRK1KITFLT3 | |
| SCHEMBL20791770 | 0.68 | NTRK1 (0.46) | MAP4K1NTRK1KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049214-A9 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-10-18 | — | — | WO | disclosed |
| WO-2018049214-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |