Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.47 |
| ▸ | GIGYF2 | Q6Y7W6 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | LOX | P28300 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.44 |
| ▸ | LY6K | Q17RY6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19952637 | 0.99 | GIGYF2 (0.46) | ITGB1ITGA4GIGYF2SORT1CA12 | |
| SCHEMBL19952750 | 0.92 | LOXL2 (0.54) | ITGB1ITGA4GIGYF2CA12CA1 | |
| SCHEMBL21067002 | 0.92 | SORT1 (0.46) | ITGB1ITGA4GIGYF2SORT1CA12 | |
| SCHEMBL19952710 | 0.92 | LOXL2 (0.53) | ITGB1ITGA4GIGYF2CA12CA1 | |
| Hydrochloric Acid SCHEMBL19952655 | 0.92 | LOXL2 (0.54) | ITGB1ITGA4GIGYF2CA12CA1 | |
| SCHEMBL19960753 | 0.92 | GIGYF2 (0.46) | ITGB1ITGA4GIGYF2SORT1CA12 | |
| Hydrochloric Acid SCHEMBL19952640 | 0.91 | LOXL2 (0.53) | ITGB1ITGA4GIGYF2CA12CA1 | |
| SCHEMBL21067001 | 0.89 | SORT1 (0.47) | ITGB1ITGA4GIGYF2SORT1CA12 | |
| SCHEMBL21066980 | 0.89 | SORT1 (0.46) | ITGB1ITGA4GIGYF2SORT1CA12 | |
| SCHEMBL19952755 | 0.87 | LOXL2 (0.52) | SORT1LOXLOXL2LY6K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510404-A1 | CHEMICAL PROBES OF LYSYL OXIDASE-LIKE 2 AND USES THEREOF | Pharmakea, Inc. (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018048928-A1 | CHEMICAL PROBES OF LYSYL OXIDASE-LIKE 2 AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |