Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25382278 | 0.75 | NOTUM (0.39) | PTGS2PTGS1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7865578 | 0.72 | ALOX5AP (0.50) | PTGS2KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8801286 | 0.69 | ALDH1A1 (0.37) | PTGS2ALDH1A1SMN1; SMN2LMNANR3C2 | |
| SCHEMBL27454511 | 0.67 | PTGS2 (0.51) | PTGS2MAOALOXL2LOX | |
| SCHEMBL8758545 | 0.65 | FGFR1 (0.45) | PTGS2PTGS1KDM4EALDH1A1RAB9A | |
| SCHEMBL28003240 | 0.65 | MAPT (0.46) | HPGD | |
| SCHEMBL8814075 | 0.63 | CYP17A1 (0.38) | PTGS2KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL31138150 | 0.63 | PTGS2 (0.34) | PTGS2KDM4E | |
| SCHEMBL28003186 | 0.63 | NR1I2 (0.48) | PTGS2PTGS1ALDH1A1RAB9ANPC1 | |
| SCHEMBL9080396 | 0.62 | ALDH1A1 (0.45) | PTGS2PTGS1KDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049014-A1 | DASH INHIBITORS, AND USES RELATED THERETO | TRUSTEES OF TUFTS COLLEGE (US) | 2018-03-15 | — | — | WO | disclosed |
| CN-100457183-C | Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination | NOVARTIS AG (CH) | 2009-02-04 | — | — | CN | disclosed |
| CN-1578674-A | Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination | NOVARTIS AG (CH) | 2005-02-09 | — | — | CN | disclosed |