Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11626476 | 0.74 | KDM4E (0.40) | ALDH1A1LMNATP53HTTPOLB | |
| SCHEMBL8814394 | 0.74 | MAPK13 (0.41) | ALDH1A1LMNAHTTP2RX7MEN1 | |
| SCHEMBL5594208 | 0.71 | ALDH1A1 (0.46) | ALDH1A1DRD2PTGS2HSD11B1MEN1 | |
| SCHEMBL8806546 | 0.70 | L3MBTL1 (0.38) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL31138150 | 0.70 | PTGS2 (0.34) | PTGS2KMT2A | |
| SCHEMBL3967152 | 0.70 | L3MBTL1 (0.50) | ALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL8758682 | 0.70 | LMNA (0.44) | ALDH1A1LMNATP53HTTSMN1; SMN2 | |
| SCHEMBL8664692 | 0.70 | RAB9A (0.42) | ALDH1A1LMNATP53HTTSMN1; SMN2 | |
| SCHEMBL19953603 | 0.69 | PTGS2 (0.41) | ALDH1A1LMNASMN1; SMN2PTGS2NR3C2 | |
| SCHEMBL7775611 | 0.69 | DRD2 (0.39) | ALDH1A1LMNATP53HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772601-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |