Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953623 | 0.83 | L3MBTL1 (0.46) | GRM7XIAPLMNATSHRMAPT | |
| SCHEMBL19953612 | 0.83 | L3MBTL1 (0.46) | GRM7XIAPLMNATSHRMAPT | |
| SCHEMBL19953510 | 0.81 | HRH3 (0.46) | GRM7TSHRMAPT | |
| SCHEMBL19953664 | 0.81 | HRH3 (0.46) | GRM7TSHRMAPT | |
| SCHEMBL19960807 | 0.81 | LMNA (0.41) | GRM7SCN9ASCN5AKCNH2XIAP | |
| SCHEMBL20113177 | 0.80 | GRM7 (0.52) | GRM7SCN9ASCN5AKCNH2 | |
| SCHEMBL19953654 | 0.79 | GRM7 (0.62) | GRM7TSHRMAPTNPSR1MCHR1 | |
| SCHEMBL19953513 | 0.79 | GRM7 (0.62) | GRM7TSHRMAPTNPSR1MCHR1 | |
| SCHEMBL20113028 | 0.78 | SCN9A (0.64) | GRM7SCN9ASCN5AKCNH2 | |
| SCHEMBL21542310 | 0.78 | RIPK1 (0.38) | GRM7SCN9ASCN5AKCNH2XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |