Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953664 | 1.00 | HRH3 (0.46) | HRH3GRM7GAAMAPTMTNR1A | |
| SCHEMBL19953654 | 0.86 | GRM7 (0.62) | HRH3GRM7GAAMAPTMTNR1A | |
| SCHEMBL19953513 | 0.86 | GRM7 (0.62) | HRH3GRM7GAAMAPTMTNR1A | |
| SCHEMBL19953768 | 0.85 | TSHR (0.50) | HRH3GRM7GAAMAPTFABP5 | |
| SCHEMBL19953636 | 0.84 | FABP5 (0.44) | HRH3GRM7GAAMAPTMTNR1A | |
| SCHEMBL19953505 | 0.83 | HRH3 (0.43) | HRH3GRM7GAAMAPTTSHR | |
| SCHEMBL19953497 | 0.81 | GRM7 (0.55) | HRH3GRM7GAAMAPTTSHR | |
| SCHEMBL19960682 | 0.81 | GRM7 (0.43) | GRM7MAPTTSHR | |
| SCHEMBL19953701 | 0.80 | ACE (0.47) | GRM7MTNR1AMTNR1B | |
| SCHEMBL19960826 | 0.80 | ACE (0.47) | GRM7MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | claimed |