Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19954265 | 0.80 | HTT (0.45) | TDP1SIGMAR1 | |
| SCHEMBL10087180 | 0.79 | CES2 (0.33) | TDP1 | |
| SCHEMBL19954143 | 0.73 | SLC6A3 (0.38) | — | |
| SCHEMBL19954142 | 0.72 | PSEN1 (0.36) | SIGMAR1 | |
| SCHEMBL10244197 | 0.72 | USP2 (0.44) | NR3C1PGRNR3C2PKM | |
| SCHEMBL15445117 | 0.72 | USP2 (0.44) | NR3C1PGRNR3C2PKM | |
| SCHEMBL13573700 | 0.72 | CES2 (0.34) | — | |
| SCHEMBL17790211 | 0.72 | ALDH1A1 (0.36) | — | |
| SCHEMBL4827313 | 0.72 | ALDH1A1 (0.36) | — | |
| SCHEMBL10244133 | 0.72 | USP2 (0.44) | NR3C1PGRNR3C2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914740-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-13 | — | — | US | disclosed |