Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25376374 | 0.83 | HTT (0.48) | HTTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL19954227 | 0.81 | ALDH1A1 (0.50) | HTTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL19954182 | 0.80 | NR3C1 (0.35) | TDP1SIGMAR1 | |
| SCHEMBL19954149 | 0.79 | SIGMAR1 (0.60) | HTTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL10315763 | 0.79 | HTT (0.46) | HTTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL14561176 | 0.79 | HTT (0.46) | HTTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL10087171 | 0.79 | HTT (0.46) | HTTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL14180879 | 0.78 | KMT2A (0.50) | HTTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL12154085 | 0.78 | KMT2A (0.50) | HTTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL14180860 | 0.75 | NPC1 (0.56) | HTTALDH1A1LMNAKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914740-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-13 | — | — | US | disclosed |