Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.44 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TGM2 | P21980 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301857 | 0.87 | ZDHHC20 (0.52) | MAPK1HIF1AZDHHC20ZDHHC2RAB9A | |
| SCHEMBL18359027 | 0.84 | ZDHHC20 (0.50) | MAPK1HIF1AZDHHC20ZDHHC2RAB9A | |
| SCHEMBL18912608 | 0.83 | MAPK1 (0.49) | MAPK1HIF1AZDHHC20ZDHHC2RAB9A | |
| SCHEMBL18231989 | 0.82 | MAPK1 (0.48) | MAPK1HIF1AZDHHC20ZDHHC2RAB9A | |
| SCHEMBL793446 | 0.79 | MAPK1 (0.46) | MAPK1HIF1AZDHHC20ZDHHC2RAB9A | |
| SCHEMBL610613 | 0.79 | MAPK1 (0.68) | MAPK1HIF1ARAB9ASMN1; SMN2GAA | |
| SCHEMBL28722817 | 0.79 | SIGMAR1 (0.47) | MAPK1HIF1AZDHHC20ZDHHC2RAB9A | |
| SCHEMBL19955066 | 0.79 | SMN1; SMN2 (0.46) | MAPK1HIF1ASMN1; SMN2TP53USP2 | |
| SCHEMBL10714041 | 0.75 | MAPK1 (0.62) | MAPK1HIF1AZDHHC20ZDHHC2RAB9A | |
| SCHEMBL17152300 | 0.74 | SMN1; SMN2 (0.41) | MAPK1HIF1ARAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914747-B2 | Extended betulinic acid analogs | VIIV Healthcare UK (No.5) Limited (GB) | 2018-03-13 | — | — | US | disclosed |