Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.42 |
| ▸ | ESR1 | P03372 | 6/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19956767 | 1.00 | DGAT1 (0.48) | DGAT1LMNAALDH1A1MAPTESR2 | |
| SCHEMBL19956766 | 0.84 | ALDH1A1 (0.39) | DGAT1LMNAALDH1A1MAPTESR2 | |
| SCHEMBL19956729 | 0.83 | DGAT1 (0.47) | DGAT1ALDH1A1ESR2ESR1CYP2C9 | |
| SCHEMBL14140575 | 0.80 | LMNA (0.40) | LMNAALDH1A1MAPTESR2ESR1 | |
| SCHEMBL22415454 | 0.78 | ESR2 (0.40) | LMNAALDH1A1MAPTESR2ESR1 | |
| SCHEMBL21101541 | 0.77 | SLC18A3 (0.41) | LMNAALDH1A1MAPTESR2SLC18A3 | |
| SCHEMBL28710893 | 0.77 | ESR2 (0.69) | DGAT1LMNAALDH1A1MAPTESR2 | |
| SCHEMBL19956743 | 0.76 | ALDH1A1 (0.35) | DGAT1LMNAALDH1A1MAPTESR2 | |
| SCHEMBL1405569 | 0.75 | ESR2 (0.50) | LMNAALDH1A1MAPTESR2ESR1 | |
| SCHEMBL10607267 | 0.74 | ESR2 (0.46) | LMNAALDH1A1MAPTESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3366686-B9 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF | METABASIS THERAPEUTICS INC (US) | 2021-08-04 | — | — | EP | disclosed |
| EP-3366686-B1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF | METABASIS THERAPEUTICS INC (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-2805951-B1 | Inhibitors of diacylglycerol o-acyltransferase 1 (DGAT-1) and uses thereof | METABASIS THERAPEUTICS INC (US) | 2018-03-14 | — | — | EP | disclosed |