Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 8/20 | 0.46 |
| ▸ | TRPC5 | Q9UL62 | 9/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYBB | P04839 | 1/20 | 0.35 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1302848 | 0.86 | NOX4 (0.55) | NOX4TRPC5MEN1GAAMAPT | |
| SCHEMBL1302632 | 0.85 | NOX4 (0.58) | NOX4TRPC5MEN1GAAMAPT | |
| SCHEMBL1302585 | 0.78 | NOX4 (0.70) | NOX4TRPC5MEN1GAAMAPT | |
| SCHEMBL1303470 | 0.75 | NOX4 (0.63) | NOX4CYBBNOX1 | |
| SCHEMBL1302503 | 0.74 | NOX4 (0.40) | NOX4TRPC5GAAMAPTCYBB | |
| SCHEMBL19956745 | 0.71 | NOX4 (0.52) | NOX4MEN1MAPTKMT2ACYBB | |
| SCHEMBL1302562 | 0.70 | NOX4 (0.67) | NOX4MEN1MAPTKMT2ACYBB | |
| SCHEMBL2219788 | 0.68 | NOX4 (0.48) | NOX4MAPTCYBBNOX5NOX1 | |
| SCHEMBL1302796 | 0.68 | NOX4 (0.46) | NOX4MEN1KMT2ACYBBNOX5 | |
| SCHEMBL19956827 | 0.68 | PGR (0.48) | NOX4MEN1GAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860179-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SUISSE SA (CH) | 2018-03-14 | — | — | EP | disclosed |